780-5 Training Level Comparison Study: Effects of Exercise Training Intensity on Insulin and Glucose Levels in Coronary Patients with “Clustering” of Risk Factors

Hyperinsulinemia has been associated with clustering of hypertension, glucose intolerance, elevated cholesterol and obesity. The effect of exercise training (Ex Tr) intensity on serum glucose (G) and insulin (I) was studied in 26 of 200 pts with documented coronary artery disease exhibiting risk factor clustering. Pts were prospectively randomized to high intensity (85% VO2max) Ex Tr or low intensity (50% VO2max) Ex Tr, 60 min., 3 week. Groups did not differ by age, weight, elevated cholesterol, hypertension or glucose intolerance at baseline. G and I levels were analyzed in the fasting state and 1 hour post glucose load at baseline and after 6 mo. of Ex Tr. Data were analyzed byWilcoxin signed rank number test and reported as medians with (ranges). There were no significant base to 6 mo. differences in fasting G and I levels in either group.Post glucose load results:Base6 MO.High Ex Tr (N=14)Low Ex Tr (N=12)High Ex Tr (N=11)Low Ex Tr (N=8)I (μ|U/ml)13613766*100(9–532)(37–1305)(11–298)(36–137)G (mg/dl)208197178**l82(161–50B)(167–400)(76–532)(137–1305)*p=0007 (within group)**p=0.002 (within group)We conclude high intensity Ex Tr appears more effective in altering postabsorptive I and G levels in coronary pts exhibiting clustering of risk factors